The port town of San Antonio, Chile, is your gateway to the capital … and Santiago de Chile, you could say, has it all. With sights ancient and modern, vibes elegant and festive, this city embodies the best of everything, and as a metropolis of over 5 million people, you could guess that it has quite a bit of it. Old and new share the stage in Santiago, with Palacio de la Real Audencia and the National Museum of History making the same must-visit list as the hip, artsy barrio Bellavista and barrio Italia neighborhoods. Nature is never far in Santiago, even in city views — imagine a neoclassical cathedral reflected in the glass of a nearby office tower, and the snow-capped Andes are usually there backdropping the sights. The beating heart of Chile's famous wine country can be found in local regions like Casablanca and Maipo Maipo Valley, contributing to the country's top-10 stature in the wine world. But while we're talking sippables, Chile's iconic pisco sour is the drink you simply shouldn't miss.